reatment of Drop ttacks in Coffin - owry Syndrome ith the Use of odium Oxybate

offin-Lowry syndrome is a well-defined clinical entity lassically associated with moderate to severe mental etardation, characteristic facial features, skeletal deforities, and tapering fingers. A characteristic paroxysmal isorder was described in up to 10% patients with offin-Lowry syndrome, characterized by sudden loss of uscle tone induced by unexpected tactile or auditory timuli. These events were given several names, including ataplexy, nonepileptic collapses with atonia, exaggerated tartle responses, hyperekplexia, and stimulus-induced rop episodes. Various therapies were undertaken for hese drop attacks, including clonazepam, tiagabine, felamate, selective serotonin reuptake inhibitors, and triyclics, with variable improvement. We report on a 2-year-old man with Coffin-Lowry syndrome with stimlus-induced drop episodes, who failed therapy with lonazepam, several antiepileptic drugs, and escitaloram, and who was given a trial of sodium oxybate with omplete resolution of the drop attacks. © 2007 by lsevier Inc. All rights reserved.